Bioactive Small Molecules
Cayman Chemical ANTIBODY AUTEN-99 10mg
An inhibitor of MRMR14/Jumpy; inhibits MTMR14/Jumpy activity in a cell-free assay at 10 and 100 µM; enhances autophagic flux and increases the levels of LC3B-11 in HeLa cells at 1 and 10 µM; increases survival of mouse primary neurons exposed to hydrogen peroxide as a model of oxidative stress at 0.5-5 µM; increases the number of autophagic structures in mouse pancreas, kidney, and liver; induces autophagy in the Drosophila larval fat body and increases the percentage of flies climbing a glass column in a climbing assay in a transgenic model of Parkinson’s disease
Cayman Chemical MT-DADMe-ImA 25mg
An MTAP inhibitor; increases MTA levels in FaDu human squamous cell carcinoma cells at 1 µM; reduces tumor growth in a FaDu mouse xenograft model at 5, 9, and 21 mg/kg per day for 28 days
Cayman Chemical ANTIBODY BAR501 5mg
A selective GP-BAR1 agonist (EC50 = 1 μM); reduces hepatic perfusion pressure and counteracts norepinephrine-induced vasoconstriction in naïve rats; protects against development of endothelial dysfunction by increasing CSE expression and activity and reducing ET-1 gene expression in rat model of cirrhosis; increases Akt-dependent phosphorylation of CSE and eNOS and inhibits ET-1 transcription in vitro; reduces trinitrobenzenesulfonic acid-induced colitis in mice in a dose-dependent manner
Cayman Chemical HPI-1hydrate 50mg
A Hh pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 µM) without affecting Wnt signaling (IC50 ≥ 30 µM); suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression; also inhibits signaling through the oncogenic mutant SmoM2
Cayman Chemical SNS-314mesylate 50mg
A pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively); inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM); inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg; inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models
Cayman Chemical PJ-34hydrochlorIde 5mg
An inhibitor of PARPs which can be used in cells or in animals; binds and inhibits the PARP TNKS1 (IC50 = 1 μM); inhibits MMP-2 when used at higher concentrations (IC50 = 56 μM)
Cayman Chemical Atrazne-d5 5mg
An internal standard for the quantification of atrazine by GC- or LC-MS
Cayman Chemical ANTIBODY WYnC 25mg
A chemoselective probe for protein sulfenylation; selective for a sulfenylated dipeptide over sulfinic acid- or sulfonic acid-containing dipeptides, reduced GSH, GSSG, and GSNO, as well as cysteine sulfinic acid and glutathione sulfonic acid in cell-free assays; selectively binds to C64,82S GPX3 containing a sulfenic acid at Cys36 over C64,82S GPX3 containing a reduced thiol, sulfinic acid at Cys36, or an intramolecular disulfide bond in cell-free assays; binds to sulfenylated proteins in live cells and can then be conjugated to azide-containing fluorescent probes for detection
Medchemexpress LLC BCI 100mg | 1245792-51-1 | 317.43 g·mol⁻¹ | C22H23NO | 100 MG
BCI is a small-molecule allosteric inhibitor of dual specificity phosphatases DUSP6 and DUSP1 supplied as a powder for laboratory research use. It has molecular formula C22H23NO, molecular weight 317.43 g·mol⁻¹, and is provided in solid pack sizes suitable for cell signaling and inflammatory disease research. Recommended storage guidance is provided for both powder and solvent solutions.
- Allosteric inhibitor of DUSP6 and DUSP1 for research use.
- High reported purity (about 99.7%).
- Supplied as a powder solid for laboratory handling.
- Available in multiple pack sizes, including 100 mg.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 2 years).
Cayman Chemical GnoderIc AcId C1 5mg
A triterpenoid; inhibits ACE (IC50 = 745 µM); inhibits HIV-1 protease (IC50 = 180 µM); reduces the proliferation of murine Lewis lung carcinoma cells but not murine Meth A sarcoma cells (EC50s = 17 and >20 UG/ml, respectively); inhibits LPS-induced NF-κB phosphorylation and production of TNF-α in RAW 264.7 cells and PBMCs isolated from patients with asthma at 20 UG/ml
TARGETMOL CHEMICALS INC SIREMADLIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Siremadlin (NVP-HDM 201) is a potent orally bioavailable and highly specific p53-MDM2 interaction inhibitor. purity: 98%
Cayman Chemical ANTIBODY CPI-613 10mg
A lipoic acid analog that inhibits α-ketoglutarate dehydrogenase, particularly in tumor cells; induces a strong mitochondrial burst of reactive oxygen species at 60-240 µM, resulting in cell death; demonstrates both in vitro and in vivo anti-tumor activity
Cayman Chemical HPI-1hydrate 25mg
A Hh pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 µM) without affecting Wnt signaling (IC50 ≥ 30 µM); suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression; also inhibits signaling through the oncogenic mutant SmoM2
Cayman Chemical ANTIBODY BIkInIn 50mg
An inhibitor of several ASK isoforms when given at a concentration of 10 µM, leaving residual kinase activity at less than 10% for ASKα, γ, ε, ζ, η, ι, and 20% for ASKθ, without inhibiting isoforms β and δ; activates signaling induced by brassinosteroids
Cayman Chemical ANTIBODY GKT137831 5mg
A dual inhibitor of both NOX1 and NOX4 with Ki values in the range of 100 to 150 nM in cell-free assays of ROS production; displays good oral bioavailability with high plasma concentrations in vivo and attenuates liver fibrosis in mice